Growing up on a council estate in Clapton, east London, Green went on to become a multi-platinum artist, with 3.5 million combined sales in the UK. He is the former co-host of Lip Sync Battle UK on Channel 5. His autobiography featured on the Times bestseller list, and he is the patron of the suicide prevention charity CALM.
In 2006, Green released his first mixtape, Lecture #1. He won the inaugural JumpOff MySpace £50,000 battle rap tournament in 2008.
After touring with Lily Allen, Professor Green was signed to Virgin Records and in 2010, Green released his debut album, Alive Till I'm Dead. His first single, "I Need You Tonight", peaked at number 3 in the UK, and number 15 in Ireland, and was certified silver in the United Kingdom.
Professor Green released his second single 'Just Be Good to Green', in 2010 in the UK, which featured British singer Lily Allen. It became a top 5 hit in the UK, a top 20 hit in Ireland and on the European Hot 100 Singles. It also peaked at #32 in New Zealand and #49 in Australia. His album was released a week later, and peaked at #2 in the UK and #18 in Ireland. He released Monster on 3 October 2010 as the third single from the album, featuring UK rapper Example (Elliot Gleave). The single became a top 30 hit on the UK Singles Chart, and the album has been certificated Gold with sales of over 100,000 in the United Kingdom.
In 2014, he appeared on a remix of "German Whip" by Meridian Dan, also featuring Skepta, Bossman Birdie and Jordan Stephens. "Not Your Man" premiered in July 2014, and was released as an "instant grat" download on iTunes when you pre-ordered the album. The album's second "instant grat" promotional single, "I Need Church", was released on 16 July. The lead single from the album, "Lullaby" featuring Tori Kelly, was released in September 2014. Growing Up in Public was released in September 2014. The album featured guest appearances from James Craise, Tori Kelly, Mr Probz, Rizzle Kicks, Whinnie Williams, Thabo, Cas and Dream Mclean.
In August 2021, Green was signed to a worldwide artist services deal with British independent record label Cooking Vinyl.
Green's autobiography, Lucky, was published in September 2015. It was a Times bestseller. Professor Green presented Suicide and Me on BBC Three on 27 October 2015. Green is also one of the 100 contributors to the book, Dear NHS: 100 Stories to Say Thank You, of which all proceeds go to NHS Charities Together and The Lullaby Trust.
Green is the patron of the anti-suicide charity CALM.