Originally gaining recognition as a member of the band Seduction, she earned five singles with the group that charted on the Billboard Hot 100. In 1993, as lead vocalist in The S.O.U.L. S.Y.S.T.E.M., she reached the top of the dance charts.
Visage became prominent in the New York drag ball scene and learned voguing from various people including Willi Ninja. She also became involved with Cesar Valentino and the pair appeared voguing together on the television show The Latin Connection in 1988, which they said was the first time voguing had appeared on national TV.
Visage auditioned and won a place for Seduction, an R&B and dance vocal trio assembled by Robert Clivilles and David Cole that signed with A&M Records in 1990. The group had several hits, the most famous being "Two to Make It Right". After the group's breakup, Visage collaborated with the freestyle dance act TKA as a guest vocalist on the song "Crash (Have Some Fun)". Visage provided lead vocals and was the recording artist of another dance act assembled by Clivilles and Cole, The S.O.U.L. S.Y.S.T.E.M.
Visage has also been featured on several of RuPaul's music albums, and appears in the music videos for "New York City Beat" and "From Your Heart", which originally premiered on RuPaul's Green Screen Christmas Special (2015), and were later uploaded to World of Wonder's YouTube channel. Visage has also made guest appearances in the videos for RuPaul's songs "Glamazon", "Responsitrannity", "The Beginning" and "Nothing for Christmas".
Michelle Visage has worked with RuPaul on a variety of television shows throughout her career. In 1996, she became the co-host of RuPaul's VH1 talk show The RuPaul Show. She also co-hosted WKTU's morning show with RuPaul from 1996 to 2002. And when Ru began casting judges for season one of RuPaul's Drag Race he invited Visage to become a permanent member of the show. At the time she was on a five-year contract with a CBS radio station in West Palm Beach and after asking her boss if she could join the show he said no, which Visage put down to the show's links with the LGBT community.
Two years later Michelle Visage was contacted by RuPaul again and invited to appear on season three of the show. After her boss once again said she was not able to appear, she was persuaded by her friend Leah Remini to contact CBS officials who allowed her to join the show as a judge. So on January 24, 2011, Visage debuted as a permanent judge, along with Santino Rice and Billy B, on season three of RuPaul's Drag Race, replacing Merle Ginsberg. She has also appeared on all seven seasons of the spin-off show, RuPaul's Drag Race All Stars.
On August 5, 2019, it was announced that Visage would be taking part in the seventeenth series of Strictly Come Dancing in the UK on BBC. On September 7, it was confirmed that she was partnered with Giovanni Pernice.